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Participation in the program is on an annual basis and standards is that animals must be allowed to behave naturally.
The following standards allow animals the opportunity to perform natural and instinctive behaviors essential to their health and well-being.
This mutagenic or potentially lethal DNA damage induces various cellular responses including cell cycle arrest, transcription alteration and processing by DNA repair mechanisms, such as the nucleotide excision repair (NER) pathway.
Disruption of NER in response to genotoxic injuries results in autosomal recessive hereditary diseases such as Xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD).
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